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Pertinax properties

Pertinax Technology

Pertinax materials are finely divided white solids. The particle size can be specified for particular applications, and a range of Pertinax materials are available with different CHX release characteristics. 

The mechanism of antimicrobial action is one of leaching of CHX ions when in contact with a moist environment. Thus Pertinax materials are stable as dry solids and must be incorporated into materials and devices as solid powders, and not dissolved as part of the formulation.  

Pertinax can be used as a component for direct topical application to skin or wounds, as a spray or cream for example. It can be used as a component materials such as polyurethane foams, acrylics, silicones and biomedical cements.

Pertinax has been shown to be efficacious against a wide range of microorganisms including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosa, Escherichia coli, Candida albicans, Streptococcus mutans, Streptococcus gordonii and Porphyromonas gingivalis.

Pertinax materials are finely divided white solids. The particle size can be specified for particular applications, and a range of Pertinax materials are available with different CHX release characteristics. 

The mechanism of antimicrobial action is one of leaching of CHX ions when in contact with a moist environment. Thus Pertinax materials are stable as dry solids and must be incorporated into materials and devices as solid powders, and not dissolved as part of the formulation.  

Pertinax can be used as a component for direct topical application to skin or wounds, as a spray or cream for example. It can be used as a component materials such as polyurethane foams, acrylics, silicones and biomedical cements.

Pertinax has been shown to be efficacious against a wide range of microorganisms including methicillin-resistant Staphylococcus aureus (MRSA), Pseudomonas aeruginosaEscherichia coliCandida albicansStreptococcus mutans, Streptococcus gordonii and Porphyromonas gingivalis.

 

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Biocompatibility of Pertinax

CHX has been investigated extensively with respect to cytotoxicity. Like many drugs, adverse effects on cells are observed when the concentration is sufficiently high.Because Pertinax releases CHX gradually, it may present a lower risk of cytotxicty than conventional CHX products. Peer-reviewed publications indiate both that Pertinax has significantly lower cytotoxicity than the equivalent concentration of CHX digluconate, and that substrates coated with Pertinax display lower cytotoxicity than commercial CHX digluconate-containing wound dressings.

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Regulatory environment

Pertinax materials will be regulated under the EU Medicines Directive as a new active pharmaceutical ingredient (API) and under the EU Biocide Regulations as a biocide depending on its intended use.

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Chlorhexidine mechanism of action

CHX is a broad-spectrum biocide. Its mechanism of action is non-specific, disrupting the microbial cell membrane, meaning that it is effective against Gram-positive bacteria, Gram-negative bacteria and fungi. CHX inactivates microorganisms with a broader spectrum than antibiotics, and operates rapidly, with a faster kill rate than some other antimicrobials such as povidone-iodine. It is either bacteriostatic (inhibits bacterial growth) or bactericidal (kills bacteria) depending on its concentration.

  • BacteriaBacteria
  • Fungi and yeastsFungi and yeasts
  • BiofilmBiofilms
CHX carries positive charge, and it binds to negatively-charged sites on the bacterial cell wall, destabilising the wall and increasing its permeability. The process is rapid, taking under a minute. At low concentration, this reduction in cell wall integrity allows the components of the cell to leach out, leading to cell death; at higher concentrations, the entry of the CHX into the cell causes the cytoplasm to solidify.

CHX’s mechanism of action against fungi is very similar to that for bacteria. The CHX impairs the integrity of the fungal cell, entering the cytoplasm resulting in leakage of cell contents and cell death. CHX is highly effective against species including Candida and Aspergillus.

Biofilms are complex, diverse and heterogeneous aggregations of microorganisms growing on a solid substrate and surrounded by a matrix of a sticky, polymer substance produced by the microorganisms. A common example is dental plaque. CHX can prevent the initial formation of biofilms and under some circumstances can disrupt established biofilms

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