Pertinax can be incorporated into polyurethane foams to create absorbed materials with excellent antimicrobial properties.
The Pertinax foams provide at least a 104 reduction in microbial growth after 24h using the AATCC100 method (Figure 1). The addition of Pertinax to the foam does not adversely affect the fluid absorption and retention properties.
Biomedical silicones can be supplemented with Pertinax to confer antimicrobial properties.
As silicones are typically hydrophobic, higher loadings of Pertinax are usually required than in other biomaterials.
Silicones used in wound care with 10% Pertinax provide zones of inhibition (Figure 1) and a 103-104 reduction in CFUs (Figure 2).
Alginates provide an excellent matrix for incorporation of Pertinax.
Pertinax alginates have an antimicrobial efficacy that can be sustained for several weeks, although most uses of alginates would require a maximum of 7-14 days, as illustrated by the zones of inhibition shown in Figure 1 and Figure 2.
Antimicrobial sutures are indicated for particular surgical procedures where the risk of post-operative infection is high. Triclosan-containing sutures have a short-term antimicrobial release, and there is also appetite for alternatives to Triclosan. Sutures supplemented with Pertinax provide excellent zones of inhibition at 24 and 48 hours, comparing favourably with commercial Triclosan sutures (Figure 6).
Pertinax can be used in topical applications such as sprays. Our Pertinax sprays utilise a combination of solvents and excipients approved for human and veterinary use which provide a fast-drying, resilient, tenacious coating that sequesters Pertinax particles, which release chlorhexidine over an extended period. These can be used for protection and treatment of wounds in animals and humans.
Methacrylate resins such as those used in dental materials can be supplemented with Pertinax. Pertinax can be used in composites, bonding agents and fissure sealants.